Septin9 Test Epi proColon
- Simple blood test for increased patient compliance
- Robust assay work flow that allows easy integration into daily laboratory routine
- Precise and highly sensitive duplex real-time PCR that detects tumor-derived DNA
The Epi proColon Early Detection Assay is based on detecting aberrantly methylated DNA of the v2 region of the Septin9 gene (SEPT9) in blood plasma.
DNA methylation is a natural and tightly controlled biological process that regulates gene expression and the stability of the genome. Every cell type has a unique DNA methylation fingerprint in normal biological processes that changes for many diseases, in particular cancer1.
Cytosine residues in the v2 region of the Septin9 gene are specifically methylated in colorectal cancer tissue but not in normal colon mucosa2.
↓ References
- Esteller, M. Relevance of DNA methylation in the management of cancer. The Lancet Oncology 4, 351–358 (2003)
- Model, F., et al. Identification and validation of colorectal neoplasia-specific methylation markers for accurate classification of disease. Mol Cancer Res 5, 153–163 (2007)
